The Effect of Maternal Cocaine Exposure on Neonatal Rat Cardiac Function

  title={The Effect of Maternal Cocaine Exposure on Neonatal Rat Cardiac Function},
  author={Lena S. Sun and Shin Takuma and Rui Lui and Shunichi Homma},
  journal={Anesthesia \& Analgesia},
Fetal cocaine exposure has been associated with a variety of cardiovascular dysfunctions in humans. We treated pregnant rats with either saline or cocaine at 60 mg/kg by gastric lavage for the entire gestational period and for 14 days after parturition. We then performed high-frequency transthoracic echocardiography to determine whether cocaine exposure affected neonatal cardiac contractile function in vivo in 7- and 14-day-old neonatal rats. All studies were performed in the unsedated… Expand
Prenatal cocaine alone and combined with nicotine alters ANG II and IGF-1 induced left atrial contractions in aging male offspring.
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Longitudinal Effects of Embryonic Exposure to Cocaine on Morphology, Cardiovascular Physiology, and Behavior in Zebrafish
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The current data shows fetal cocaine exposure has significant immediate and long-term cardiac consequences in animal models and while human studies are still incomplete they suggest this phenomenon may also be significant in humans exposed to cocaine during development. Expand
Effect of prenatal cocaine on early postnatal thermoregulation and ultrasonic vocalization production
Findings indicate that prenatal cocaine may be altering the elicitation of maternal care through its impact on vocalizations and thermoregulation, and suggests a potential mechanism for these effects through cocaine's impact on developing stress systems. Expand
Effects of Prenatal Cocaine on Maternal Care and Ultrasonic Vocalizations of Rat Offspring
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Dobutamine stress echocardiography in healthy adult male rats
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The Housekeeping Gene (GA3PDH) and the Long Interspersed Nuclear Element (LINE) in the Blood and Organs of Rats Treated with Cocaine
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A Rodent Model of Cocaine’s Effect on the Mother Infant Dyad


Perinatal Cocaine Exposure Impairs Myocardial &bgr;-Adrenoceptor Signaling in the Neonatal Rat
  • L. Sun
  • Medicine
  • Anesthesia and analgesia
  • 2000
Perinatal cocaine exposure impaired the myocardial &bgr;AR-cAMP signaling pathway during the first week of postnatal life in the rat, showing that maternal cocaine use during pregnancy impairs the &b gr;-adrenoceptor signaling pathway in theRat during thefirst week of life. Expand
Prenatal cocaine exposure alters norepinephrine release from cardiac adrenergic nerve terminals.
The results suggest that prenatal cocaine exposure delays the development of the mechanisms responsible for Ca2+ influx during K(+)-induced depolarization and increases the neurosecretory response to intracellular Ca2+. Expand
Heart rate variability in neonatal rats after perinatal cocaine exposure.
There were normal developmental changes in HRV consistent with continued postnatal development of autonomic nervous system and perinatal cocaine exposure appeared to modify these changes. Expand
Decreased cardiac output in infants of mothers who abused cocaine.
It was speculated that an increase in plasma norepinephrine levels is responsible for the cardiovascular effects of intrauterine cocaine exposure. Expand
Transient myocardial ischemia in infants prenatally exposed to cocaine.
It is concluded that cocaine use in pregnant mothers is associated with transient ST segment abnormalities in their infants that are consistent with transient myocardial ischemia. Expand
Circulating catecholamine concentrations in cocaine-exposed neonates: a pilot study.
Preliminary data from a pilot study suggest that catecholamine activity is increased in cocaine-exposed newborns and may play a role in neurobehavioral disturbances associated with prenatal exposure to this drug. Expand
Heart rate variability in cocaine-exposed newborn infants.
Lower heart rate variability was seen in cocaine-exposed infants andvagal parameters such as high-frequency power and the square root of the mean of the squared differences between adjacent N-N intervals were lower in newborns with heavy in utero cocaine exposure. Expand
Elevated plasma norepinephrine after in utero exposure to cocaine and marijuana.
Plasma NE is increased in newborns exposed to cocaine and marijuana and is associated with selected neurobehavioral disturbances among cocaine exposed infants at 1 to 3 days of life but not at 2 weeks. Expand
Fetal and maternal brain and plasma levels of cocaine and benzoylecgonine following chronic subcutaneous administration of cocaine during gestation in rats
The results of the present study suggest that the subcutaneous route may prove to be an appropriate means in rats for administering cocaine prenatally in investigations designed to assess potential neurobehavioral ramifications of gestational cocaine exposure. Expand
Changes in sensitivity of rat heart to norepinephrine and isoproterenol during pre- and postnatal development and its relation to sympathetic innervation.
The observed parallelism between functional sympathetic innervation and postjunctional sensitivity changes supports the hypothesis that sympathetic nerve exerts trophic influence upon cardiac muscle development to regulate the sensitivity to agonists. Expand