The Effect of Ivermectin on Convulsions in Rats Produced by Lidocaine and Strychnine

@article{Trailovi2007TheEO,
  title={The Effect of Ivermectin on Convulsions in Rats Produced by Lidocaine and Strychnine},
  author={Sa{\vs}a M. Trailovi{\'c} and Vladislav M. Varagic},
  journal={Veterinary Research Communications},
  year={2007},
  volume={31},
  pages={863-872}
}
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods. However, ivermectin and other avermectins very often produce side-effects in hosts. The most dominant clinical symptom of ivermectin toxicity in domestic and wild animals is CNS depression. In nematodes, the target site of ivermectin’s action is glutamate-gated chloride-channel receptor and GABA receptor. The depressive effect of… CONTINUE READING

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Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods .
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods .
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods .
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods .
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods .
Ivermectin is one of the most commonly used drugs in pharmacotherapy of parasitic diseases in domestic and wild animals caused by parasitic nematodes and arthropods .
Furthermore , flumazenil ( 0.1 and 0.2 mg / kg ) , an antagonist of benzodiazepine receptors , antagonizes just one part of these anticonvulsive effects of ivermectin .
BenzodiazepinesContraindicating class ofFlumazenil
Furthermore , flumazenil ( 0.1 and 0.2 mg / kg ) , an antagonist of benzodiazepine receptors , antagonizes just one part of these anticonvulsive effects of ivermectin .
Furthermore , flumazenil ( 0.1 and 0.2 mg / kg ) , an antagonist of benzodiazepine receptors , antagonizes just one part of these anticonvulsive effects of ivermectin .
In nematodes , the target site of ivermectin ’s action is glutamate - gated chloride - channel receptor and GABA receptor .
In nematodes , the target site of ivermectin ’s action is glutamate - gated chloride - channel receptor and GABA receptor .
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