The Effect of Intraoperative Blood Loss on Serum Cefazolin Level in Patients Undergoing Instrumented Spinal Fusion: A Prospective, Controlled Study

@article{Polly1996TheEO,
  title={The Effect of Intraoperative Blood Loss on Serum Cefazolin Level in Patients Undergoing Instrumented Spinal Fusion: A Prospective, Controlled Study},
  author={D. Polly and J. Meter and R. Brueckner and L. Asplund and B. V. van Dam},
  journal={Spine},
  year={1996},
  volume={21},
  pages={2363–2367}
}
Study Design This study is a prospective, controlled study of the effect of intraoperative and postoperative blood loss during spinal surgery on serum cefazolin level. Objectives To determine what effect, if any, intraoperative blood loss has on serum antibiotic levels, and to determine if adjustment of the dose or dose interval is appropriate in operative cases of significant blood loss. Summary of Background Data The problem of infection at the operative site after posterior spinal fusion… Expand
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Serum antibiotic levels, measured at 30-min intervals, declined with a half-life of 90 min, similar to the previously reported experience with normal adult volunteers, and there was no relationship between serum half- life and blood loss or fluid replacement. Expand
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TLDR
Preoperatively, seventy-one patients who were to have total hip arthroplasty were given one gram of cephalothin, cephradine, or cefazolin intravenously, and peak levels in bone, reached twenty-five to forty minutes after injection, were sixty, 6.7, and fifteen times higher than the usual mean minimum inhibitory concentrations, respectively, for penicillin-resistant staphylococci. Expand
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The level of airborne bacterial contamination in the operating room can be reduced by limiting the traffic and controlling the activity and the number of operating room personnel. Expand
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