The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes Mellitus

@article{Nathan1993TheEO,
  title={The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes Mellitus},
  author={David M Nathan and Saul M. Genuth and John M. Lachin and Patricia A. Cleary and O. Crofford and Matthew Davis and Lawrence I Rand and Carolyn Siebert},
  journal={Survey of Anesthesiology},
  year={1993},
  volume={38},
  pages={173}
}
BACKGROUND Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM. [] Key MethodMETHODS A total of 1441 patients with IDDM--726 with no retinopathy at base line (the primary-prevention cohort) and 715 with mild retinopathy (the secondary-intervention cohort) were randomly assigned to intensive therapy administered either with an external insulin pump or by three or more daily insulin injections and guided by…

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Insulin therapy, hyperglycemia, and hypertension in type 1 diabetes mellitus.

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