The Effect of Inflammatory Cytokines in Alcoholic Liver Disease

  title={The Effect of Inflammatory Cytokines in Alcoholic Liver Disease},
  author={Hideto Kawaratani and Tatsuhiro Tsujimoto and Akitoshi Douhara and Hiroaki Takaya and Kei Moriya and Tadashi Namisaki and Ryuichi Noguchi and Hitoshi Yoshiji and Masao Fujimoto and Hiroshi Fukui},
  booktitle={Mediators of inflammation},
Alcohol is the most common cause of liver disease in the world. Chronic alcohol consumption leads to hepatocellular injury and liver inflammation. Inflammatory cytokines, such as TNF-α and IFN-γ, induce liver injury in the rat model of alcoholic liver disease (ALD). Hepatoprotective cytokines, such as IL-6, and anti-inflammatory cytokines, such as IL-10, are also associated with ALD. IL-6 improves ALD via activation of the signal transducer and activator of transcription 3 (STAT3) and the… CONTINUE READING