The Effect of Immune Selection on the Structure of the Meningococcal Opa Protein Repertoire

@article{Callaghan2008TheEO,
  title={The Effect of Immune Selection on the Structure of the Meningococcal Opa Protein Repertoire},
  author={Martin J. Callaghan and Caroline O. Buckee and Keith A. Jolley and Paula Kriz and Martin C J Maiden and Sunetra Gupta},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={499 - 510}
}
The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles. We analysed the Opa repertoire… CONTINUE READING