The Effect of Hyperoxic Exposure on Antioxidant Enzyme Activities of Alveolar Type II Cells in Neonatal and Adult Rats

@article{Keeney1992TheEO,
  title={The Effect of Hyperoxic Exposure on Antioxidant Enzyme Activities of Alveolar Type II Cells in Neonatal and Adult Rats},
  author={Susan E. Keeney and Samuel E Cress and Susan E. Brown and Akhil Bidani},
  journal={Pediatric Research},
  year={1992},
  volume={31},
  pages={441-444}
}
ABSTRACT: Neonatal animals of several species are more tolerant of hyperoxic exposure than arc adults, but the mechanisms of increased neonatal tolerance are unknown, as are the cell types, if any, that contribute to oxygen resistance. We studied the effect of in vivo exposure to 85% oxygen for 72 h on the activities of the antioxidant enzymes, glutathionc peroxidase, catalase and superoxide disnwtase (SOD), in alveolar type II cells and whole lung from adult and neonatal rats. Baseline… CONTINUE READING

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Molecular mechanisms of hyperoxia-induced acute lung injury.

Frontiers in bioscience : a journal and virtual library • 2008

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