The Effect of Growth-Mimicking Continuous Strain on the Early Stages of Skeletal Development in Micromass Culture

@inproceedings{Klumpers2015TheEO,
  title={The Effect of Growth-Mimicking Continuous Strain on the Early Stages of Skeletal Development in Micromass Culture},
  author={Darinka D. Klumpers and Theodoor Henri Smit and David J Mooney},
  booktitle={PloS one},
  year={2015}
}
Embryonic skeletogenesis involves proliferation, condensation and subsequent chondrogenic differentiation of mesenchymal precursor cells, and the strains and stresses inherent to these processes have been hypothesized to influence skeletal development. The aim of this study was to determine the effect of growth-mimicking strain on the process of early skeletal development in vitro. To this end, we applied continuous uniaxial strain to embryonic skeletal precursor cells in micromass culture… CONTINUE READING

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