The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

@article{Tarutani2016TheEO,
  title={The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.},
  author={Airi Tarutani and Genjiro Suzuki and Aki Shimozawa and Takashi Nonaka and Haruhiko Akiyama and Shin-ichi Hisanaga and Masato Hasegawa},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 36},
  pages={18675-88}
}
Aggregates of abnormal proteins are widely observed in neuronal and glial cells of patients with various neurodegenerative diseases, and it has been proposed that prion-like behavior of these proteins can account for not only the onset but also the progression of these diseases. However, it is not yet clear which abnormal protein structures function most efficiently as seeds for prion-like propagation. In this study, we aimed to identify the most pathogenic species of α-synuclein (α-syn), the… CONTINUE READING