The Effect of Fermented Papaya Preparation on Radioactive Exposure

@inproceedings{Fibach2015TheEO,
  title={The Effect of Fermented Papaya Preparation on Radioactive Exposure},
  author={Eitan Fibach and Eliezer A. Rachmilewitz},
  booktitle={Radiation research},
  year={2015}
}
Exposure to ionizing radiation causes cellular damage, which can lead to premature cell death or accumulation of somatic mutations, resulting in malignancy. The damage is mediated in part by free radicals, particularly reactive oxygen species. Fermented papaya preparation (FPP), a product of yeast fermentation of Carica papaya Linn, has been shown to act as an antioxidant. In this study, we investigated the potential of FPP to prevent radiation-induced damage. FPP (0–100 μg/ml) was added to… 

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References

SHOWING 1-10 OF 40 REFERENCES

Radiation-induced oxidative DNA damage, 8-oxoguanine, in human peripheral T cells.

It remains necessary to evaluate the extent of radiation-induced oxidative DNA damage and it is important to analyze superoxide radical production and scavenging in terms of the variety of radiosensitivities found among various types of normal tissue cells and neoplastic cells.

Iron, free radicals and cancer

  • P. Reizenstein
  • Medicine, Biology
    Medical oncology and tumor pharmacotherapy
  • 1991
While iron-deficiency anemia should of course be diagnosed, treated and if possible prevented, there are good reasons to avoid over-utilization of medicamental iron.

The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity

Investigation of the antioxidant potential of fermented papaya preparation (FPP), a product of yeast fermentation of Carica papaya Linn, under conditions that prevail in the oral cavity suggested that these enhancing effects were due to the solubilization of antioxidant polyphenols in FPP by saliva proteins and the binding to RBC and microorganisms, thus increasing their availability and activity.

The comet assay for DNA damage and repair

The comet assay (single-cell gel electrophoresis) is a simple method for measuring deoxyribonucleic acid (DNA) strand breaks in eukaryotic cells that has applications in testing novel chemicals for genotoxicity, monitoring environmental contamination with genotoxins, human biomonitoring and molecular epidemiology, and fundamental research in DNA damage and repair.

Assays of cell viability: discrimination of cells dying by apoptosis.

Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype

Preliminary data show that FPP is a promising nutraceutical for improving antioxidant‐defense in elderly patients even without any overt antioxidant‐deficiency state while helping explain some inconsistent results of prior interventional studies.

Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

It is now apparent that non-targeted delayed effects such as RIGI are also important post-irradiation outcomes, and epigenetics may be the missing link in understanding the mechanism behind RIGi.