The Effect of Fermented Papaya Preparation on Radioactive Exposure

  title={The Effect of Fermented Papaya Preparation on Radioactive Exposure},
  author={Eitan Fibach and Eliezer A. Rachmilewitz},
  booktitle={Radiation research},
Exposure to ionizing radiation causes cellular damage, which can lead to premature cell death or accumulation of somatic mutations, resulting in malignancy. The damage is mediated in part by free radicals, particularly reactive oxygen species. Fermented papaya preparation (FPP), a product of yeast fermentation of Carica papaya Linn, has been shown to act as an antioxidant. In this study, we investigated the potential of FPP to prevent radiation-induced damage. FPP (0–100 μg/ml) was added to… 

Oral Administration of Fermented Papaya (FPP®) Controls the Growth of a Murine Melanoma through the In Vivo Induction of a Natural Antioxidant Response

The results showed that FPP® controlled tumor growth, reducing the tumor mass of about three to seven times vs. untreated mice, and a potent anti-oxidant treatment through FPP may contribute to both preventing and inhibiting tumors growth.

Oxidative Stress in β-Thalassemia

The role of oxidative stress and the current and potential antioxidative therapeutics in β-thalassemia are summarized and some methodologies, mostly cellular, that might be helpful for application of a theranostics approach to therapy are described.

Beneficial Effects of Fermented Papaya Preparation (FPP®) Supplementation on Redox Balance and Aging in a Mouse Model

Early treatment of Fermented Papaya Preparation resulted to be more effective, suggesting a potential key role of FPP® in preventing the age-related molecular damages.

Carica papaya: Potential Implications in Human Health

Papaya aqueous leaf extract was evaluated for immunomodulatory and anti-tumor activities through cytokine modulation with Th1 type shift in human immune system through molecular studies.

Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast

The Adverse Outcome Pathway (AOP) framework is used to outline and evaluate the evidence linking ionizing radiation with breast cancer from molecular initiating events to the adverse outcome through intermediate key events, creating a qualitative AOP.



Radiation-induced oxidative DNA damage, 8-oxoguanine, in human peripheral T cells.

It remains necessary to evaluate the extent of radiation-induced oxidative DNA damage and it is important to analyze superoxide radical production and scavenging in terms of the variety of radiosensitivities found among various types of normal tissue cells and neoplastic cells.

Iron, free radicals and cancer

  • P. Reizenstein
  • Medicine, Biology
    Medical oncology and tumor pharmacotherapy
  • 1991
While iron-deficiency anemia should of course be diagnosed, treated and if possible prevented, there are good reasons to avoid over-utilization of medicamental iron.

The Antioxidant Effect of Fermented Papaya Preparation in the Oral Cavity

Investigation of the antioxidant potential of fermented papaya preparation (FPP), a product of yeast fermentation of Carica papaya Linn, under conditions that prevail in the oral cavity suggested that these enhancing effects were due to the solubilization of antioxidant polyphenols in FPP by saliva proteins and the binding to RBC and microorganisms, thus increasing their availability and activity.

The comet assay for DNA damage and repair

The comet assay (single-cell gel electrophoresis) is a simple method for measuring deoxyribonucleic acid (DNA) strand breaks in eukaryotic cells that has applications in testing novel chemicals for genotoxicity, monitoring environmental contamination with genotoxins, human biomonitoring and molecular epidemiology, and fundamental research in DNA damage and repair.

Assays of cell viability: discrimination of cells dying by apoptosis.

Nutraceutical Supplementation: Effect of a Fermented Papaya Preparation on Redox Status and DNA Damage in Healthy Elderly Individuals and Relationship with GSTM1 Genotype

Preliminary data show that FPP is a promising nutraceutical for improving antioxidant‐defense in elderly patients even without any overt antioxidant‐deficiency state while helping explain some inconsistent results of prior interventional studies.

Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

It is now apparent that non-targeted delayed effects such as RIGI are also important post-irradiation outcomes, and epigenetics may be the missing link in understanding the mechanism behind RIGi.