The Effect of Escalating Dose, Multiple Binge Methamphetamine Regimen and Alcohol Combination on Spatial Memory and Oxidative Stress Markers in Rat Brain

  title={The Effect of Escalating Dose, Multiple Binge Methamphetamine Regimen and Alcohol Combination on Spatial Memory and Oxidative Stress Markers in Rat Brain},
  author={Ladan Vaghef and Shirin Babri and M MoghaddamVahed},
  journal={Journal of alcoholism and drug dependence},
Polydrug abuse is a major problem around the world. Methamphetamine (MA) and alcohol (AL) are two abused drugs which are frequently used together. Chronic abuse of either MA or AL causes oxidative stress in the brain and is associated with impairments in cognitive functions including various aspects of memory and learning. The present study examined the effect of escalating dose, multiple binge MA regimen, AL and MA-AL combination on spatial memory and the induction of oxidative stress in the… Expand
Methamphetamine-Induced Brain Injury and Alcohol Drinking
Prior EtOH drinking causes an increase in inflammatory mediators that mediate a synergistic interaction with Meth to cause an enhanced neurotoxicity, which is correlated with the degree of EtOH consumption. Expand
Combined and sequential effects of alcohol and methamphetamine in animal models
Evidence for additive or synergistic effects of combined or sequential exposure on behavior and physiology is found and dopaminergic, serotonergic, and glutamatergic systems are all impacted by combined exposure to alcohol and methamphetamine. Expand
Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid
The aim of this article is to review the consequences of alcohol’s interaction with other drugs and decipher the underlying mechanisms that have been one of the key hindrances in developing effective treatments. Expand
Alcohol Interactions with Psychostimulants: An Overview of Animal and Human Studies
Co-abuse of alcohol with psychostimulants during pregnancy can lead to fetal brain abnormalities and further studies are needed to investigate the pharmacokinetics, pharmacodynamics, and neurochemical changes on co-abuse. Expand
Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra
Data show that repeated escalating MA induces several compensatory mechanisms, such as mitochondrial biogenesis and elevation in GDNF in SN, which can reverse MA‐induced neuroinflammation and prevent TH‐immunoreactivity reduction in nigrostriatal pathway. Expand
Conditional Effects of Lifetime Alcohol Consumption on Methamphetamine-Associated Neurocognitive Performance
Contrary to expectations, greater lifetime alcohol use related to reduced risk of neurocognitive impairment among MA users, supported by prior research identifying neurobiological mechanisms by which alcohol may attenuate stimulant-driven vasoconstriction and brain thermotoxicity. Expand
Alcohol Consumption- Influence on Global Population
Liquor keeps on being a standout amongst the most often mishandled medications on the planet, and its utilization is connected with the main sources of death among youth and the most elevated amount of utilization is seen in created countries. Expand
Effects of Modulating Glutamate Homeostasis in Methamphetamine and Alcohol Co-Abuse: Potential Therapeutic Targets
............................................................................................................................. iii AcknowledgementsExpand


Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats
It is suggested that mechanisms other than or additional to the decrement in striatal DA associated with an acute METH binge are responsible for the deficit in the NOR task, and that neuroadaptations consequential to prolonged escalating dose METH pretreatment mitigate against these mechanisms. Expand
Differential neurochemical consequences of an escalating dose‐binge regimen followed by single‐day multiple‐dose methamphetamine challenges
Pre‐treatment‐induced partial protection against monoamine depletion is probably not because of attenuated METH‐induced hyperthermia in those rats, whereas METH pre‐treated animals that received the 6 × 5 mg/kg METH challenge showed comparable increases in temperatures to saline pre‐ treated rats. Expand
Effects of methamphetamine and ethanol on learning and brain neurotransmitters in rats
Support is provided for the direct antagonistic and indirect additive interactions following constant daily treatment with a combination of MAMP and EtOH, which may be an important factor in MAMP abuse to MAMP-induced psychosis or neurotoxicity. Expand
Repeated co-administrations of alcohol- and methamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus
The results suggest that repeated co-administrations of MA and EtOH may produce an observable anxiogenic effect, which could be associated with neuronal loss in the dentate gurus and less likely related to this combination-caused glial toxicity in limbic regions or cell proliferation-inhibiting effect in the SVZ or DG. Expand
Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat
It is suggested that selective degeneration of pyramidal neurons and interneurons in the neocortex and limbic system might be involved in the cognitive alterations in METH users. Expand
Effect of methamphetamine exposure and cross-fostering on cognitive function in adult male rats
It is indicated that postnatal but not prenatal exposure to MA affects learning in adult male rats, however, it is still not clear whether these impairments are due to a direct effect of MA on neuronal structure or due to an indirect effect ofMA mediated by impaired maternal care. Expand
Acute and residual interactive effects of repeated administrations of oral methamphetamine and alcohol in humans
Data show that methamphetamine combined with alcohol produced a profile of effects that was different from the effects of either drug alone, which might explain why these drugs are often used in combination. Expand
Methamphetamine Self-Administration Is Associated with Persistent Biochemical Alterations in Striatal and Cortical Dopaminergic Terminals in the Rat
The results suggest that meth self-administration by rats is associated with long-term biochemical changes that are reminiscent of those observed in post-mortem brain tissues of chronic meth abusers. Expand
Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge
It is suggested that further study of the effects produced by a regimen which includes a gradual escalation of doses prior to high-dose METH binge exposure could more accurately identify the neurochemical and behavioral changes relevant to those that occur as a consequence of high- dose METH abuse in humans. Expand
Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice.
A neurotoxic/binge regimen of MA in mice that produces the typical pattern of neurotoxic changes to those seen in rats, results in few behavioral changes, which may limit the utility of C57BL/6 mice for modeling the cognitive and behavioral effects described in human MA users who show such changes even after prolonged abstinence. Expand