The Effect of Escalating Dose, Multiple Binge Methamphetamine Regimen and Alcohol Combination on Spatial Memory and Oxidative Stress Markers in Rat Brain

@article{Vaghef2014TheEO,
  title={The Effect of Escalating Dose, Multiple Binge Methamphetamine Regimen and Alcohol Combination on Spatial Memory and Oxidative Stress Markers in Rat Brain},
  author={Ladan Vaghef and Shirin Babri and M MoghaddamVahed},
  journal={Journal of alcoholism and drug dependence},
  year={2014},
  volume={2},
  pages={1-10}
}
Polydrug abuse is a major problem around the world. Methamphetamine (MA) and alcohol (AL) are two abused drugs which are frequently used together. Chronic abuse of either MA or AL causes oxidative stress in the brain and is associated with impairments in cognitive functions including various aspects of memory and learning. The present study examined the effect of escalating dose, multiple binge MA regimen, AL and MA-AL combination on spatial memory and the induction of oxidative stress in the… Expand
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