The Effect of Echinacea (Echinacea purpurea Root) on Cytochrome P450 Activity in Vivo

@article{Gorski2004TheEO,
  title={The Effect of Echinacea (Echinacea purpurea Root) on Cytochrome P450 Activity in Vivo},
  author={Jude Christopher Gorski and Shiew-Mei Huang and Amar G. Pinto and Mitchell A. Hamman and Janna Hilligoss and Narjis A. Zaheer and Mehul Desai and Margaret Miller and Stephen D. Hall},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2004},
  volume={75}
}

Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir‐Ritonavir Exposure in Healthy Subjects

Study Objective. To determine the influence of Echinacea purpurea on the pharmacokinetics of lopinavir‐ritonavir and on cytochrome P450 (CYP)3A and P‐glycoprotein activity by using the probe

Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co‐varies with alkylamide content

Echinacea preparations are one of the best selling herbal medicinal products with a well established therapeutic use in the prophylaxis of upper respiratory tract infections, but information about their ability to inhibit cytochrome P450 enzymes (CYP) is fragmentary and a lack of phytochemical characterization of previously tested preparations is complicated.

The in‐vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity

The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates

ECHINACEA PURPUREA - A POTENT IMMUNOSTIMULANT Review Article

Echinacea purpurea L. is one among the plant with both pharmacological and the properties of the aesthetic enjoyment that was found to contain immunostimulant, antileishmanial, cytochrome p450, apoptotic – mitotic and anti‐microbial activities.

Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression

It is concluded that Echinaforce is unlikely to affect CYP3A4 transcriptional levels, even at concentrations which can inhibit the enzymatic activity of CYP4, and provides further evidence for the lack of interactions between Echinacea and conventional drugs.

Interactions of echinacea and spilanthes with human metabolizing systems

Spilanthol, the only major isobutyl amide found in the ethanolic preparation of Spilanthes acmella whole flowering plant was isolated and it showed strong inhibitory properties against CYP2E1.

The effect of Echinacea purpurea on the pharmacokinetics of docetaxel.

The applied E. purpurea product at the recommended dose may be combined safely with docetaxel in cancer patients and did not significantly alter the pharmacokinetics of docetAXel in this study.
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