The Effect of Echinacea (Echinacea purpurea Root) on Cytochrome P450 Activity in Vivo
@article{Gorski2004TheEO, title={The Effect of Echinacea (Echinacea purpurea Root) on Cytochrome P450 Activity in Vivo}, author={Jude Christopher Gorski and Shiew-Mei Huang and Amar G. Pinto and Mitchell A. Hamman and Janna Hilligoss and Narjis A. Zaheer and Mehul Desai and Margaret Miller and Stephen D. Hall}, journal={Clinical Pharmacology \& Therapeutics}, year={2004}, volume={75} }
310 Citations
In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto
- Medicine, BiologyClinical pharmacology and therapeutics
- 2004
Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir‐Ritonavir Exposure in Healthy Subjects
- Biology, ChemistryPharmacotherapy
- 2010
Study Objective. To determine the influence of Echinacea purpurea on the pharmacokinetics of lopinavir‐ritonavir and on cytochrome P450 (CYP)3A and P‐glycoprotein activity by using the probe…
Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co‐varies with alkylamide content
- Biology, ChemistryThe Journal of pharmacy and pharmacology
- 2007
Echinacea preparations are one of the best selling herbal medicinal products with a well established therapeutic use in the prophylaxis of upper respiratory tract infections, but information about their ability to inhibit cytochrome P450 enzymes (CYP) is fragmentary and a lack of phytochemical characterization of previously tested preparations is complicated.
In Vivo Effects of Goldenseal, Kava Kava, Black Cohosh, and Valerian on Human Cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 Phenotypes
- BiologyClinical pharmacology and therapeutics
- 2005
The in‐vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity
- Biology, MedicineThe Journal of pharmacy and pharmacology
- 2014
The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates…
ECHINACEA PURPUREA - A POTENT IMMUNOSTIMULANT Review Article
- Biology
- 2012
Echinacea purpurea L. is one among the plant with both pharmacological and the properties of the aesthetic enjoyment that was found to contain immunostimulant, antileishmanial, cytochrome p450, apoptotic – mitotic and anti‐microbial activities.
Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression
- BiologyEvidence-based complementary and alternative medicine : eCAM
- 2011
It is concluded that Echinaforce is unlikely to affect CYP3A4 transcriptional levels, even at concentrations which can inhibit the enzymatic activity of CYP4, and provides further evidence for the lack of interactions between Echinacea and conventional drugs.
Interactions of echinacea and spilanthes with human metabolizing systems
- Chemistry
- 2006
Spilanthol, the only major isobutyl amide found in the ethanolic preparation of Spilanthes acmella whole flowering plant was isolated and it showed strong inhibitory properties against CYP2E1.
Evaluation of the impact of Polygonum capitatum, a traditional Chinese herbal medicine, on rat hepatic cytochrome P450 enzymes by using a cocktail of probe drugs.
- Biology, MedicineJournal of ethnopharmacology
- 2014
The effect of Echinacea purpurea on the pharmacokinetics of docetaxel.
- Medicine, BiologyBritish journal of clinical pharmacology
- 2013
The applied E. purpurea product at the recommended dose may be combined safely with docetaxel in cancer patients and did not significantly alter the pharmacokinetics of docetAXel in this study.
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