The Effect of Drugs and Other Compounds on the Ciliary Beat Frequency of Human Respiratory Epithelium

@article{Workman2014TheEO,
  title={The Effect of Drugs and Other Compounds on the Ciliary Beat Frequency of Human Respiratory Epithelium},
  author={Alan D. Workman and Noam A Cohen},
  journal={American Journal of Rhinology \& Allergy},
  year={2014},
  volume={28},
  pages={454 - 464}
}
  • A. Workman, N. Cohen
  • Published 1 November 2014
  • Medicine
  • American Journal of Rhinology & Allergy
Background Cilia in the human respiratory tract play a critical role in clearing mucus and debris from the airways. Their function can be affected by a number of drugs or other substances, many of which alter ciliary beat frequency (CBF). This has implications for diseases of the respiratory tract and nasal drug delivery. This article is a systematic review of the literature that examines 229 substances and their effect on CBF. Methods MEDLINE was the primary database used for data collection… 
View on SAGE
ncbi.nlm.nih.gov
35 Citations
Background Citations
13

35 Citations

Citation Type

Citation Type

A pilot study exploring the impact of cardiac medications on ciliary beat frequency: possible implications for clinical management
TLDR
The medications frequently used in cardiac intensive care unit impact ciliary function, with most being ciliodepressant.
Effect of Cellulose Powder on Human Nasal Epithelial Cell Activity and Ciliary Beat Frequency
TLDR
Cytotoxicity and the suppression of ciliary beat at high concentrations justify more prudent use of CP for the management of AR.
Ciliary beat frequency of in vitro human nasal epithelium measured with the simple high-speed microscopy is applicable for safety studies of nasal drug formulations.
Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors
TLDR
It is concluded that selective (PDE1, PDE4, or dual PDE inhibitors) increase the intracellular level of cyclic nucleotides in airway epithelial cells and thus may be an important target in the development of new inhaled mucokinetic agents.
Acute and Chronic Effects of Oral Erdosteine on Ciliary Beat Frequency, Cough Sensitivity and Airway Reactivity.
TLDR
It is concluded that erdosteine may directly contribute to mucus clearance by CBF stimulation and its mild bronchodilator and mucolytic properties may promote effective cough.
In Vitro Ciliotoxicity and Cytotoxicity Testing of Repeated Chronic Exposure to Topical Nasal Formulations for Safety Studies
TLDR
This study demonstrates a dose-dependent and time-dependent effect of the nasal sprays on ciliary activity and cytotoxicity using CBF measurements and ultrastructural analysis, respectively and suggests that such in vitro assays have great potential for topical nasal drug screening.
Airway Epithelial Cell Cilia and Obstructive Lung Disease
TLDR
More research is needed to determine the structural-functional regulation of ciliary beating via all signaling pathways and how this might relate to the initiation or progression of obstructive lung diseases.
Measurement of ciliary beat frequency using ultra-high resolution optical coherence tomography
TLDR
OCT has been used to study the retina in ophthalmology as well as vasculature in cardiology, and offers higher resolution than conventional computed tomography and magnetic resonance imaging, and the lab specifically developed an ultra-high resolution OCT system to image the microstructure of the ciliated epithelial cells.
Mucociliary Clearance: Measures and Therapies
TLDR
Therapy for Mucociliary Clearance includes proteolytic enzymes to reduce mucus viscosity, vibrations for improving ciliary beat frequency, irrigation with Locke-Ringer's solution for cilia frequency, glucosteroids and surfactants and other toxic products.
Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19.
TLDR
Saline interacts at various levels relevant to nasal or respiratory hygiene (nasal irrigation, gargling or aerosol) and may represent a useful add-on to first-line interventions for COVID-19, if used from the onset of common cold symptoms.
...
1
2
3
4
...

References

SHOWING 1-10 OF 219 REFERENCES
Effect of atropine on ciliary beat in human upper respiratory tract epithelial cells.
TLDR
The authors' data show a drop in in vitro CBF following atropine infusion which, presumably, reflects a fall in the in vivo efficacy of mucociliary transport, which was inversely correlated with increasing age.
Factors affecting ciliary function in vitro: a preliminary study.
TLDR
It is suggested that alpha and beta receptors may be present on ciliated epithelium and be involved in the control of ciliary function in vivo and Ion fluxes across the ciliary cell membrane may also be important in ciliary activity akin to nervous tissue.
Effect of bacterial products on human ciliary function in vitro.
TLDR
It is concluded that Ps aeruginosa and H influenzae release a factor (or factors) which causes slowing of human nasal cilia in vitro, and the role of this factor in the pathogenesis of infection is discussed.
The Effects of Sinus Bacteria on Human Ciliated Nasal Epithelium in Vitro
TLDR
Ciliary activity of the nasal epithelium in the presence of each pathogen was assessed for more than 240 minutes with a photometric method of ciliary beat frequency (CBF) measurement, and H. influenzae and S. epidermidis disrupted normal synchronous ciliary motion, causing adjacent cilia to beat at different rates.
Topical Antibiotic, Antifungal, and Antiseptic Solutions Decrease Ciliary Activity in Nasal Respiratory Cells
TLDR
The results indicate that topical application of antifungal, antibiotic, and antiseptic solutions may cause a marked impairment of mucociliary clearance and indicates the need for a careful selection of the adequate concentration when using topical treatment in the nose.
Validation of animal experiments on ciliary function in vitro. II. The influence of absorption enhancers, preservatives and physiologic saline.
TLDR
It is concluded that chicken embryo trachea can be used as a substitute for human ciliated mucosa when studying ciliary activity in vitro.
Beneficial effect of antibiotics on ciliary beat frequency of human nasal epithelial cells exposed to bacterial toxins
TLDR
It is suggested that topical antibiotic treatment of nasal infections could result in a dual positive effect, namely treatment of the bacterial infection and recovery of ciliary activity.
Validation of animal experiments on ciliary function in vitro. I. The influence of substances used clinically.
TLDR
The experiments show that chicken trachea constitutes a valid substitute for human material in studying ciliary activity in vitro, and provides evidence in support of the assumption that cryopreservation has no effect on ciliary reactivity as expressed by the CBF.
Mechanistic appraisal of the effects of some protease inhibitors on ciliary beat frequency in a sequential cell culture system of human nasal epithelium.
Influence of Essential and Fatty Oils on Ciliary Beat Frequency of Human Nasal Epithelial Cells
TLDR
Test the influence of fatty and essential oils on the ciliary beat frequency (CBF) of nasal mucosa in vivo found that the presence of most fatty oils resulted in an increase in CBF, the effect being highest for peanut oil.
...
1
2
3
4
5
...