The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

Abstract

A super-saturated self-nanoemulsifying drug delivery system (super-SNEDDS), containing the poorly water-soluble drug halofantrine (Hf) at 150% of equilibrium solubility (S eq), was compared in vitro and in vivo with a conventional SNEDDS (75% of S eq) with respect to bioavailability and digestibility. Further, the effect of digestion on oral absorption of… (More)
DOI: 10.1208/s12248-015-9832-7

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Cite this paper

@article{Michaelsen2015TheEO, title={The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)}, author={Maria H\otoft Michaelsen and Kishor M. Wasan and Olena A. Sivak and Anette M{\"u}llertz and Thomas Rades}, journal={The AAPS Journal}, year={2015}, volume={18}, pages={180-186} }