The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations

@article{Wu2016TheEO,
  title={The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations},
  author={Chien‐Chih Wu and Tsung-Yu Pai and Fei‐Yuan Hsiao and Li-Jiuan Shen and Fe-Lin Lin Wu},
  journal={Therapeutic Drug Monitoring},
  year={2016},
  volume={38},
  pages={587–592}
}
Background: Carbapenem antibiotics (CBPMs) may significantly reduce the serum concentration of valproic acid (VPA), but the extent of this effect among various CBPMs is unknown. This study compared the extent and onset of the interactions among ertapenem, imipenem/cilastatin, and meropenem. Methods: A 5-year retrospective study was performed. Hospitalized patients over 18 years old who received VPA and a CBPM concurrently were enrolled via the pharmacy computer system. Patients who lacked VPA… 
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