The Effect of Dietary Nitrate Supplementation on Endurance Exercise Performance in Healthy Adults: A Systematic Review and Meta-Analysis

  title={The Effect of Dietary Nitrate Supplementation on Endurance Exercise Performance in Healthy Adults: A Systematic Review and Meta-Analysis},
  author={Nicholas F. McMahon and Michael D Leveritt and Toby G. Pavey},
  journal={Sports Medicine},
BackgroundRecent research into the use of dietary nitrates and their role in vascular function has led to it becoming progressively more popular amongst athletes attempting to enhance performance.ObjectiveThe objective of this review was to perform a systematic review and meta-analysis of the literature to evaluate the effect of dietary nitrate (NO3−) supplementation on endurance exercise performance. An additional aim was to determine whether the performance outcomes are affected by potential… 

Effect of dietary nitrate ingestion on muscular performance: a systematic review and meta-analysis of randomized controlled trials

Dietary nitrate seems to have a positive effect on muscular strength and muscular endurance, which is mostly unaffected by dosage, frequency of ingestion, training level, muscle group, or type of contraction.

The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis

The available evidence suggests that dietary nitrate supplementation benefits performance-related outcomes for endurance sports.

Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review

This systematic review examines the existing evidence basis for NO3− supplementation to improve muscular power, velocity of contraction, and muscular endurance during weightlifting exercise in healthy adults and discusses the potential mechanistic bases for any positive effects of NO3+ supplementation on resistance exercise performance.

Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis

Acute or chronic dietary NO 3 − intake significantly increases maximal muscle power in humans and the magnitude of this effect–on average, ~ 5%–is likely to be of considerable practical and clinical importance.

Impact of dietary nitrate supplementation on exercise capacity and cardiovascular parameters in chronic respiratory disease: a systematic review and meta-analysis

Dietary nitrate supplementation may have a beneficial effect on BP and augment the effect of pulmonary rehabilitation on exercise capacity, but short-term studies do not suggest a consistent benefit on exercisecapacity.

Influence of Nitrate Supplementation on Endurance Cyclic Sports Performance: A Systematic Review

Improvement in exercise tolerance was obtained, which could help with exhaustion over time, while the improvement in exercise economics was not as clear, and further studies are required to understand the factors that affect the potential ergogenic impacts of nitrate on athletic performance among endurance athletes.

Effects of Nitrate Supplementation on Exercise Performance in Humans: A Narrative Review

The current recommendation of nitrate supplementation is discussed, as well as possible health complications associated with nitrate intake for athletes, and dietary strategies of covering nitrate needs through sufficient intake of nitrates-rich foods alone are presented.

Effects of Dietary Nitrates on Time Trial Performance in Athletes with Different Training Status: Systematic Review

There might be a fibre-type specific role in nitric oxide production and, therefore, supplement of ergogenicity in time trial performance after increased dietary nitrate intake, according to VO2max and recent histological observations of muscle fibres.

Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis

Supplemental digital content is available in the text. ABSTRACT Although over 100 studies and reviews have examined the ergogenic effects of dietary nitrate (NO3−) supplementation in young, healthy



The effect of nitrate supplementation on exercise performance in healthy individuals: a systematic review and meta-analysis.

Overall, these results suggest that nitrate supplementation is associated with a moderate improvement in constant load time to exhaustion tasks and the small positive effect on time trial or graded exercise performance may be meaningful in an elite sport context.

Aerobic Fitness Affects the Exercise Performance Responses to Nitrate Supplementation.

It is suggested that the individual aerobic fitness level affects the ergogenic benefits induced by dietary nitrate supplementation and the optimal nitrate loading regimen required to elevate plasma [NO2] and to enhance performance in elite athletes is different from that of low-fit subjects and requires further studies.

Acute dietary nitrate supplementation improves cycling time trial performance.

It is suggested that acute dietary nitrate supplementation with 0.5 L of BR improves cycling economy, as demonstrated by a higher PO for the same VO2 and enhances both 4- and 16.1-km cycling TT performance.

Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans.

The reduced O(2) cost of exercise following dietary NO(3)(-) supplementation appears to be due to a reduced ATP cost of muscle force production.

Sodium nitrate supplementation does not enhance performance of endurance athletes.

Sodium nitrate supplementation did not improve a 40-min distance-trial performance in endurance athletes and concentration of plasma ET-1 increased significantly after exercise after supplementation with sodium nitrate.

Dietary nitrate does not enhance running performance in elite cross-country skiers.

Acute ingestion of dietary nitrate may not represent an effective strategy for reducing the oxygen cost of submaximal exercise or for enhancing endurance exercise performance in highly trained cross-country skiers.

Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.

The reduced O2 cost of exercise following increased dietary nitrate intake has important implications for the understanding of the factors that regulate mitochondrial respiration and muscle contractile energetics in humans.

Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study.

The results indicate that the positive effects of 6 days of BR supplementation on the physiological responses to exercise can be ascribed to the high NO(3)(-) content per se.

Effect of acute dietary nitrate intake on maximal knee extensor speed and power in healthy men and women.