The Effect of DNA Repair Defects on Reproductive Performance in Nucleotide Excision Repair (NER) Mouse Models: An Epidemiological Approach

@article{Tsai2005TheEO,
  title={The Effect of DNA Repair Defects on Reproductive Performance in Nucleotide Excision Repair (NER) Mouse Models: An Epidemiological Approach},
  author={Po Yi Tsai and Mirjam Nielen and G. A. van der Horst and Ben Colenbrander and J.A.P. Heesterbeek and J. Martje Fentener van Vlissingen},
  journal={Transgenic Research},
  year={2005},
  volume={14},
  pages={845-857}
}
In this study, we used an epidemiological approach to analyze an animal database of DNA repair deficient mice on reproductive performance in five Nucleotide Excision Repair (NER) mutant mouse models on a C57BL/6 genetic background, namely CSA, CSB, XPA, XPC [models for the human DNA repair disorders Cockayne Syndrome (CS) and xeroderma pigmentosum (XP), respectively] and mHR23B (not associated with human disease). This approach allowed us to detect and quantify reproductive effects based on a… CONTINUE READING

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