The Effect of Coronary Inflow Pressure on Coronary Vascular Resistance in the Isolated Dog Heart

@article{Hanley1984TheEO,
  title={The Effect of Coronary Inflow Pressure on Coronary Vascular Resistance in the Isolated Dog Heart},
  author={Frank Louis Hanley and Louis M. Messina and Mark T. Grattan and Julien I.E. Hoffman},
  journal={Circulation Research},
  year={1984},
  volume={54},
  pages={760–772}
}
The shape of the coronary arterial pressure-flow relationship results from the interaction of a number of poorly understood physiological factors. Experiments in which coronary inflow and outflow pressures were coupled so that driving pressure was held constant showed that changes in inflow or outflow pressures altered coronary blood flow: coronary vascular resistance varied inversely with changes in inflow pressure below 50 mm Hg and with changes in outflow pressure below 80 mm Hg. The… 
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The presence of interarterial perfusion pressure gradients between the left anterior descending artery and the remaining vessels resulted in an increase in zero flow pressure and a more linear slope of the P-F relationship to the same degree in both the beating and non-beating states, indicating that collateral circulation is not necessarily inhibited by cardiac contraction.
Effects of the pericardium on the diastolic left coronary pressure-flow relationship in the isolated dog heart.
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The effects of the pericardium on diastolic left coronary pressure-flow relationships in heart-blocked and isolated canine preparations and their slopes were approximated by a linear regression analysis in which the correlation coefficients were greater than .98 in all cases.
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TLDR
In systole, there is no evidence for typical waterfalls, but more evidence in favor of regional changes in intramyocardial compliance to explain coronary pressure-flow relationships is needed.
Effects of increased pressure inside or outside ventricles on total and regional myocardial blood flow.
TLDR
Raising pressures inside or outside the heart shifts pressure-flow curves and raises P(zf) by increasing coronary venous pressure, and the effects are most prominent in the subendocardial muscle layer.
Comments on "Interpretation and physiological significance of diastolic coronary artery pressure-flow relationships in the canine coronary bed".
TLDR
It is shown that the marked decrease in crosssectional area caused by a slight decrease in pressure is similar to what has been found for collapsible tubes, if a pressure-dependent nonlinear resistor can act.
Characterization of capacitance-free pressure-flow relations during single diastoles in dogs using an RC model with pressure-dependent parameters.
TLDR
A simple, lumped diastolic model with pressure-dependent parameters can predict capacitance-free pressure-flow behavior from dynamic pressure- flow data and characterize model parameters over a wide range of coronary pressure.
Physiological Basis of Clinically Used Coronary Hemodynamic Indices
TLDR
It is shown that the coronary system is intrinsically nonlinear because resistance vessels at maximal vasodilation change diameter with pressure and cardiac function and that clinical studies of coronary physiology will benefit greatly from combined measurements of coronary flow or velocity and pressure.
Coronary Diastolic Pressure‐Flow Relation and Zero Flow Pressure Explained on the Basis of Intramyocardial Compliance
  • J. Spaan
  • Medicine, Engineering
    Circulation research
  • 1985
TLDR
An attempt has been made to estimate the compliance distribution within the coronary circulation and to show the specific effect of intramyocardial compliance on arterial and venous pressure-flow relations, and it is predicted that overall intramYocardial Compliance may exceed epicardial arterial compliance by a factor 45.
Left coronary pressure-flow relations of the beating and arrested rabbit heart at different ventricular volumes.
Coronary pressure-flow relations as basis for the understanding of coronary physiology.
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References

SHOWING 1-10 OF 21 REFERENCES
Diastolic Coronary Artery Pressure‐Flow Relations in the Dog
  • R. Bellamy
  • Medicine, Engineering
    Circulation research
  • 1978
Conscious dogs were used to investigate the relations between aortic (Pa) pressure and coronary flow (F) during individual diastoles. When the dogs were in a semibasal state, coronary pressure-flow…
Effect of coronary sinus occlusion on coronary pressure-flow relations.
TLDR
The data are not compatible with the existence of a vascular waterfall mechanism in the coronary circulation unless it is assumed that Pcv is one of the determinants of Pf = 0, and the level of Pcv below which changes in Pcv had no effect on the coronary pressure-flow relation.
Influence of Autoregulation and Capacitance on Diastolic Coronary Artery Pressure‐Flow Relationships in the Dog
TLDR
Diastolic coronary artery pressure-flow relations obtained when pressure is continuously changing are influenced by coronary vascular capacitance, which is consistent with a vascular waterfall model of diastolic flow regulation.
The Effects of the Coronary Capacitance on the Interpretation of Diastolic Pressure‐Flow Relationships
TLDR
It is concluded that coronary capacitive effects and resistance changes during diastole severely limit the interpretation of instantaneous dynamic P/F relationships.
Inhibition of Coronary Blood Flow by a Vascular Waterfall Mechanism
TLDR
It is concluded that systole inhibits coronary perfusion by the formation of vascular waterfalls and that the intramyocardial pressures responsible for this inhibition do not significantly exceed peak ventricular pressure.
Regulation of Coronary Blood Flow during Individual Diastoles in the Dog
TLDR
During constant pressure perfusion, diastolic coronary vascular resistance is constant during diastole, and when coronary resistance is actively changing, regulation of coronary blood flow occurs continuously during individual diastoles.
Ventricular filling pressure as a determinant of coronary blood flow during ischemia.
TLDR
The findings demonstrate the importance of VFP as a determinant of CBF during ischemia, and they lend support to the concept that blood flow in the ischemic ventricle is regulated by a preload-dependent transmural gradient in coronary driving pressure.
Zero-flow pressures and pressure-flow relationships during single long diastoles in the canine coronary bed before and during maximum vasodilation. Limited influence of capacitive effects.
TLDR
It is concluded that P(f=0) is a quantitatively important determinant of coronary driving pressure and flow, resulting from both factors related to, and independent of, vasomotor tone.
Greater Coronary Vascular Reserve in Dogs Anesthetized with Halothane
TLDR
Dogs lightly anesthetized with halothane have greater coronary vascular reserves than do dogs anesthenized with nitrous oxide, and minimal coronary vascular resistances are similar with the two anesthetic regimens.
A nondestructive technique to measure wall displacement in the thoracic aorta.
TLDR
A simple, highly precise, nonsurgical technique to follow aortic wall motion and consequently monitor pulsatile changes in thoracic aorta diameter is presented.
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