The Effect of Commonly Used Excipients on the Epithelial Integrity of Human Cervicovaginal Tissue.

  title={The Effect of Commonly Used Excipients on the Epithelial Integrity of Human Cervicovaginal Tissue.},
  author={Minlu Hu and Tian Zhou and Charlene S. Dezzutti and Lisa Cencia Rohan},
  journal={AIDS research and human retroviruses},
  volume={32 10-11},
Pharmaceutical excipients are widely used in vaginal drug products. The epithelial integrity of the cervicovaginal tissue is important for HIV-1 prevention. However, the effects of excipients on cervicovaginal epithelium remain unknown. This study aims at assessing the effects of vaginal product excipients on the integrity of human cervicovaginal epithelium and on a lead HIV prevention antiretroviral drug, tenofovir (TFV). In the current study, nine excipients commonly used in vaginal… Expand
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