The Effect of Certain Conditions in the Regulation of Cystathionine γ-Lyase by Exogenous Hydrogen Sulfide in Mammalian Cells

  title={The Effect of Certain Conditions in the Regulation of Cystathionine $\gamma$-Lyase by Exogenous Hydrogen Sulfide in Mammalian Cells},
  author={Maoxian Wang and Zhanyun Guo and Shilong Wang},
  journal={Biochemical Genetics},
  pages={503 - 513}
Cystathionine γ-lyase (CSE), one of three enzymes in the trans-sulfuration pathway, is responsible for the production of endogenous hydrogen sulfide (H2S) using l-cysteine or l-homocysteine as a substrate. The regulatory mechanism of CSE by exogenous H2S remains unknown. The transcription and expression of the CSE gene regulated by exogenous H2S at approximately physiologic concentrations was investigated using luciferase assay, Western blotting, and quantitative RT-PCR. The results revealed… 

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