The Effect of Baclofen and AP-7 on Selected Behavior in Rats

  title={The Effect of Baclofen and AP-7 on Selected Behavior in Rats},
  author={Halina Car and Kapuscinski Wi},
  journal={Pharmacology Biochemistry and Behavior},
  • H. Car, K. Wi
  • Published 1 March 1998
  • Biology, Psychology
  • Pharmacology Biochemistry and Behavior
Effects of baclofen and L-AP4 in passive avoidance test in rats after hypoxia-induced amnesia.
It is concluded that baclofen and L-AP4 may cooperate in the consolidation process in rats without Hypoxia and in retrieval of passive avoidance in animals that had undergone hypoxia.
AIDA influences behavior in rats pretreated with baclofen.
AIDA significantly reduced the effect of baclofen on this memory process in rats pretreated with bacl ofen, which later received AIDA, and AIDA did not influence the behavior of rats pretreatment with baclofen in comparison with the group treated with bacanofen alone.
Baclofen prevents hypoxia-induced consolidation impairment for passive avoidance in rats.
It is concluded that baclofen improved consolidation of passive avoidance in rats undergoing hypoxia, a model of experimentally induced amnesia, and exhibited anxiolytic effect.
Effect of short- and long-term administration of baclofen on spatial learning and memory in rats.
It is revealed that baclofen did not affect spatial learning at any of the tested doses and regardless of the length of administration, and memory was observed to be affected, but only at the highest dose of bacl ofen and only temporarily.
Baclofen alters flash-evoked potentials in Long–Evans rats
NMDA receptor antagonists change behavioral activity of rats treated with (S)-4CPG.
The hypothesis concerning the co-operation between group I mGluRs and NMDA receptors in some behavioral tests and the modulating effect of group I gluRs antagonist on central action of NMDA receptor antagonists is supported.
Effects of CA1 glutamatergic systems upon memory impairments in cholestatic rats
Role of GABAB receptors in learning and memory and neurological disorders


Modulation of learning processes by ionotropic glutamate receptor ligands.
The present paper reviews the literature dealing with the role of NMDA receptor antagonists in learning and possible consequences for the therapy of dementia, and suggests that positive modulation of these receptors could result in cognitive enhancement that might find therapeutic application.
The estimation of interactions between arginine-vasopressin (AVP) and NMDA receptors in memory and learning processes.
The results of this study show that noncompetitive antagonist of NMDA receptor-MK-801 impairs the effect of AVP on the consolidation of conditioned avoidance responses and antagonist of polyamines site-arcaine reduced advantageous effect on the retrieval of memory in passive avoidance situation.
Long‐Term GABA Treatment Elicits Supersensitivity of Quisqualate‐Preferring Metabotropic Glutamate Receptor in Cultured Rat Cerebellar Neurons
Observations suggest the involvement of GABAA receptors and the apparent development of tolerance to GABA, respectively, and dependence on GABA may have occurred; the metabotropic effects of glutamate, kainate, and quisqualate were not altered in neurons maintained with GABA treatment.
Role of GABA during the multiple consolidation of memory
The anatomical evidence on the presence of GABAergic neurons in brain areas relevant to memory like the cortex, amygdala, septum, hippocampus and NBM, together with the electrophysiological and biochemical changes induced by the learning experience, suggest that the neurons can critically modulate the electrical activity of these brain areas during the “multiple consolidation” process of memory storage.