The Effect of Atractylate and Oligomycin on the Behaviour of Mitochondria towards Adenine Nucleotides.

1. Investigation of a number of reactions involving both internal and externally added adenine nucleotides of isolated liver mitochondria has revealed that atractylate and oligomycin differ markedly in the site of their inhibitory action. 2. Both atractylate and oligomycin inhibited the respiratory-chain-level phosphorylation of added ADP. Neither compound… (More)