The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

@inproceedings{Lewis1993TheEO,
  title={The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy},
  author={Edmund J. Lewis and Lawrence G. Hunsicker and Raymond P. Bain and Richard D. Rohde},
  year={1993}
}
Background Renal function declines progressively in patients who have diabetic nephropathy, and the decline may be slowed by antihypertensive drugs. The purpose of this study was to determine whether captopril has kidney-protecting properties independent of its effect on blood pressure in diabetic nephropathy. Methods We performed a randomized, controlled trial comparing captopril with placebo in patients with insulin-dependent diabetes mellitus in whom urinary protein excretion was ≥ 500 mg… CONTINUE READING

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