The Effect of Aminoguanidine and Tolrestat on Glucose Toxicity in Bovine Retinal Capillary Pericytes

  title={The Effect of Aminoguanidine and Tolrestat on Glucose Toxicity in Bovine Retinal Capillary Pericytes},
  author={R. Chibber and P. Molinatti and J. S. Wong and D. Mirlees and E. M. Kohner},
  pages={758 - 763}
  • R. Chibber, P. Molinatti, +2 authors E. M. Kohner
  • Published 1994
  • Biology, Medicine
  • Diabetes
  • Cultured bovine retinal capillary pericytes (BRP) were used to investigate the effect of an aldose reductase inhibitor, tolrestat, and an inhibitor of advanced glycation end products (AGE) formation, aminoguanidine, on glucose toxicity. Glucose at high concentration reduced the replicative activity of pericytes in a dose-dependent manner. Tolrestat completely inhibited the production of sorbitol in cells exposed to a high concentration of glucose but failed to protect the cells from glucose… CONTINUE READING
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