Corpus ID: 56248463

The Effect of Aging on Glucose Tolerance and B Cell Secretion in Man Wpływ wieku na tolerancję glukozy i czynność wydzielniczą komórek B wysp trzustkowych

  title={The Effect of Aging on Glucose Tolerance and B Cell Secretion in Man Wpływ wieku na tolerancję glukozy i czynnoś{\'c} wydzielniczą kom{\'o}rek B wysp trzustkowych},
  author={M. Jasik and W. Karnafel and Z. Zdrojewicz},
Objectives. The aim of the study was to evaluate the influence of aging on glucose tolerance, B cell secretion and hepatic clearance of insulin. Material and Methods. 100 subjects of both sexes, aged between 17 and 92, of BMI < 27 kg/m 2 were studied. All subjects were divided into 4 groups according to their age: 18 patients aged 17–59 (group I – mean age 46 ± 12 (SD) years), 23 patients aged 60–69 (group II – mean age 64 ± 3 years), 33 patients aged 70–79 (group III – mean age 75 ± 3 years… Expand


Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin
In conclusion, under the present experimental conditions, employing intravenous glucose and/or insulin, impaired tissue sensitivity to insulin is the primary factor responsible for the decrease in glucose tolerance observed with advancing age. Expand
Effects of aging on plasma islet amyloid polypeptide basal level and response to oral glucose load.
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Mechanism of Increased Plasma Glucose Levels after Oral Glucose Ingestion in Normal-Weight Middle-Aged Subjects
In normal-weight middle-aged individuals, glucose intolerance is mainly due to the reduction in the mass of fat-free glucose-utilizing tissues, which enables normal glucose supply to peripheral tissues, and increase splanchnic glucose uptake. Expand
Influence of Aging on Hepatic and Peripheral Glucose Metabolism in Humans
It is concluded that age-related glucose intolerance develops despite slowed glucose absorption and is characterized by delays in the initial rise in insulin levels, the suppression of HGO, and the rise in peripheral glucose uptake, which is predominantly the result of impaired peripheral glucose utilization. Expand
Age or waist as determinant of insulin action?
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Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)
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Influence of Aging on Insulin Receptor Binding and Metabolic Effects of Insulin on Human Adipose Tissue
It is concluded that aging is accompanied by impairment of the action of insulin on target cells, owing to alterations at both the receptor and the postreceptor levels, which may be essential factors in the development of relative glucose intolerance in the aged. Expand
Age as Independent Determinant of Glucose Tolerance
Fatness, fitness, and fat distribution can account for the decline in glucose tolerance from the young adult to the middle-aged years, however, age remains a significant determinant of the further decline in sugars tolerance of healthy old subjects. Expand
Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging.
To assess the effect of exercise training on the insulin resistance and impaired pancreatic B-cell function of aging, we studied 13 healthy older men (ages 61-82 yr) before and after 6 mo intensiveExpand
Effect of Habitual Physical Activity on Regulation of Insulin‐stimulated Glucose Disposal in Older Males
The results demonstrated that insulin‐stimulated glucose disposal was significantly increased in the normal older subjects who exercised regularly, and a direct relationship existed between maximal aerobic capacity and in vivo insulin action, which was independent of either BMI or percentage body fat. Expand