The Ebola virus ribonucleoprotein complex: a novel VP30-L interaction identified.

  title={The Ebola virus ribonucleoprotein complex: a novel VP30-L interaction identified.},
  author={Allison Groseth and Jean Enno Charton and Markus Sauerborn and Friederike Feldmann and Steven J. M. Jones and Thomas Hoenen and Heinz Feldmann},
  journal={Virus research},
  volume={140 1-2},
The ribonucleoprotein (RNP) complex of Ebola virus (EBOV) is known to be a multiprotein/RNA structure, however, knowledge is rather limited regarding the actual protein-protein interactions involved in its formation. Here we show that singularly expressed VP35 and VP30 are present throughout the cytoplasm, while NP forms prominent cytoplasmic inclusions and L forms smaller perinuclear inclusions. We could demonstrate the existence of NP-VP35, NP-VP30 and VP35-L interactions, similar to those… CONTINUE READING


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