The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress.

@article{AduGyamfi2013TheEV,
  title={The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress.},
  author={Emmanuel Adu-Gyamfi and Smita P. Soni and Yi Xue and Michelle A Digman and Enrico Gratton and Robert V. Stahelin},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 8},
  pages={
          5779-89
        }
}
Ebola, a fatal virus in humans and non-human primates, has no Food and Drug Administration-approved vaccines or therapeutics. The virus from the Filoviridae family causes hemorrhagic fever, which rapidly progresses and in some cases has a fatality rate near 90%. The Ebola genome encodes seven genes, the most abundantly expressed of which is viral protein 40 (VP40), the major Ebola matrix protein that regulates assembly and egress of the virus. It is well established that VP40 assembles on the… CONTINUE READING

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