The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress.

@article{Soni2013TheEV,
  title={The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress.},
  author={Smita P. Soni and Emmanuel Adu-Gyamfi and Sylvia S Yong and Clara S. Jee and Robert V. Stahelin},
  journal={Biophysical journal},
  year={2013},
  volume={104 9},
  pages={
          1940-9
        }
}
Ebola virus, from the Filoviridae family has a high fatality rate in humans and nonhuman primates and to date, to the best of our knowledge, has no FDA approved vaccines or therapeutics. Viral protein 40 (VP40) is the major Ebola virus matrix protein that regulates assembly and egress of infectious Ebola virus particles. It is well established that VP40 assembles on the inner leaflet of the plasma membrane; however, the mechanistic details of VP40 membrane binding that are important for viral… CONTINUE READING

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