The Early Decrease in N-Acetyl Aspartate / Glutathione , a Brain Health Marker , Induced by Vitamin A Deprivation in Rat is Reversed by Retinoic Acid †

@inproceedings{Beauvieux2009TheED,
  title={The Early Decrease in N-Acetyl Aspartate / Glutathione , a Brain Health Marker , Induced by Vitamin A Deprivation in Rat is Reversed by Retinoic Acid †},
  author={M. C. Beauvieux and Nadirah Ghenimi Rahab and Gerard Raffard and Val{\'e}rie Enderlin and nique Pallet and Paul Higueret and Jean-Louis Gallis},
  year={2009}
}
Retinoids are involved in adult brain function and in neurodegenerative diseases. Decreased expression of synaptic plasticity markers and metabolic changes induced by 14 weeks of vitamin A deprivation (VAD14) were previously evidenced in rat brain. We evaluate early metabolic changes (by HRMAS proton NMR spectroscopy) on biopsies of cortex, hippocampus and striatum (i) during VAD and (ii) after all trans Retinoic Acid administration. In 10 wk VAD (VAD10), metabolic changes appeared in the… CONTINUE READING

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