The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector

@inproceedings{Hemmi2014TheEA,
  title={The Early Activation of CD8+ T Cells Is Dependent on Type I IFN Signaling following Intramuscular Vaccination of Adenovirus Vector},
  author={Masahisa Hemmi and Masashi Tachibana and Sayaka Tsuzuki and Masaki Shoji and Fuminori Sakurai and Kenji Kawabata and Kouji Kobiyama and Ken J Ishii and Shizuo Akira and Hiroyuki Mizuguchi},
  booktitle={BioMed research international},
  year={2014}
}
Few of the vaccines in current use can induce antigen- (Ag-) specific immunity in both mucosal and systemic compartments. Hence, the development of vaccines that realize both mucosal and systemic protection against various pathogens is a high priority in global health. Recently, it has been reported that intramuscular (i.m.) vaccination of an adenovirus vector (Adv) can induce Ag-specific cytotoxic T lymphocytes (CTLs) in both systemic and gut mucosal compartments. We previously revealed that… CONTINUE READING
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References

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Structural basis of a unique interferon-β signaling axismediated via the receptor IFNAR1

  • N. A. deWeerd, J. P. Vivian, T. K. Nguyen
  • Nature Immunology, vol. 14, no. 9, pp. 901–907…
  • 2013
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