The EXACT-Pro: measuring exacerbations of COPD.

  title={The EXACT-Pro: measuring exacerbations of COPD.},
  author={Bartolome R Celli and Joergen Vestbo},
  journal={American journal of respiratory and critical care medicine},
  volume={183 3},
During the natural course of chronic obstructive pulmonary disease (COPD), the majority of patients will develop acute episodes of worsening of symptoms that differ from the day-today variations, and may require alterations in therapy. These episodes have been named exacerbations. The change in symptoms has been used to define them clinically (1, 2), while a change in therapy (usually corticosteroids or antibiotics) is used to define them ‘‘operationally’’ in clinical trials or reports from… CONTINUE READING
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