The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour

@article{Lee1997TheET,
  title={The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour},
  author={Sean Bong Lee and Kathryn Ann Kolquist and Kim E Nichols and Christoph Englert and S. Maheswaran and Marc Ladanyi and William L. Gerald and Daniel A. Haber},
  journal={Nature Genetics},
  year={1997},
  volume={17},
  pages={309-313}
}
Chromosomal translocations resulting in chimaeric transcription factors underlie specific malignancies, but few authentic target genes regulated by these fusion proteins have been identified. Desmoplastic small round-cell tumour (DSRT) is a multiphenotypic primitive tumour characterized by massive reactive fibrosis surrounding nests of tumour cells1. The t(11;22)(p13;q12) chromosomal translocation that defines DSRT produces a chimaeric protein containing the potential transactivation domain of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Similar Papers

Loading similar papers…