The ESR properties, DNA nicking, and DNA association of aged solutions of catechol versus aqueous extracts of tar from cigarette smoke.

@article{Stone1995TheEP,
  title={The ESR properties, DNA nicking, and DNA association of aged solutions of catechol versus aqueous extracts of tar from cigarette smoke.},
  author={Kim Stone and Edilberto Bermudez and L Y Zang and Karen M Carter and K E Queenan and William A. Pryor},
  journal={Archives of biochemistry and biophysics},
  year={1995},
  volume={319 1},
  pages={196-203}
}
Previous studies in our laboratories have shown that extracts from mainstream or sidestream tobacco smoke nick DNA. These solutions contain the tar semiquinone free radical, and the tar radical becomes associated with cellular DNA. Aged solutions of catechol contain a semiquinone species that has ESR properties similar to those of the radical in cigarette tar extracts, and we have used these catechol solutions as a model for the tar radical. Both the radical in aged catechol solutions and the… CONTINUE READING

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