The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

@article{Raiborg2009TheEM,
  title={The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins},
  author={Camilla Raiborg and Harald Stenmark},
  journal={Nature},
  year={2009},
  volume={458},
  pages={445-452}
}
Selective trafficking of membrane proteins to lysosomes for destruction is required for proper cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins should be transported to the lysosome lumen by the multivesicular endosome pathway. The endosomal sorting complex required for transport (ESCRT) machinery sorts cargo labelled with ubiquitin into invaginations of endosome membranes. Then, through a highly conserved mechanism also used in cytokinesis and viral… 
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