The ESCRT machinery: from the plasma membrane to endosomes and back again.

  title={The ESCRT machinery: from the plasma membrane to endosomes and back again.},
  author={Amber L. Schuh and Anjon Audhya},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={49 3},
The manipulation and reorganization of lipid bilayers are required for diverse cellular processes, ranging from organelle biogenesis to cytokinetic abscission, and often involves transient membrane disruption. A set of membrane-associated proteins collectively known as the endosomal sorting complex required for transport (ESCRT) machinery has been implicated in membrane scission steps, which transform a single, continuous bilayer into two distinct bilayers, while simultaneously segregating… CONTINUE READING
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