The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis.

@article{Seger2001TheES,
  title={The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis.},
  author={Reinhard Seger and Tamar Hanoch and Revital Rosenberg and Ada Dantes and Wolfgang E Merz and Jerome F Strauss and Abraham Amsterdam},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={
          13957-64
        }
}
The response of granulosa cells to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is mediated mainly by cAMP/protein kinase A (PKA) signaling. Notably, the activity of the extracellular signal-regulated kinase (ERK) signaling cascade is elevated in response to these stimuli as well. We studied the involvement of the ERK cascade in LH- and FSH-induced steroidogenesis in two granulosa-derived cell lines, rLHR-4 and rFSHR-17, respectively. We found that stimulation of these cells… CONTINUE READING

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