The ERK signaling cascade--views from different subcellular compartments.

  title={The ERK signaling cascade--views from different subcellular compartments.},
  author={Zhong Yao and Rony Seger},
  volume={35 5},
The extracellular signal-regulated kinase cascade is a central signaling pathway that is stimulated by various extracellular stimuli. The signals of these stimuli are then transferred by the cascade's components to a large number of targets at distinct subcellular compartments, which in turn induce and regulate a large number of cellular processes. To achieve these functions, the cascade exhibits versatile and dynamic subcellular distribution that allows proper temporal and spatial modulation… CONTINUE READING

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