The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation

@article{Crpieux2001TheES,
  title={The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation},
  author={Pascale Cr{\'e}pieux and Sebastien Marion and Nadine Martinat and V{\'e}ronique Fafeur and Yves Le Vern and Dominique Kerboeuf and Florian Guillou and Eric Reiter},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={4696-4709}
}
Primary cultures of Sertoli cells provide an interesting model to study how signalling pathways induced by a single hormone in a single cell type evolve, depending on the developmental stage. In vivo, follicle-stimulating hormone (FSH) induces proliferation of Sertoli cells in neonate and controls the subsequent differentiation of the entire population. Molecular mechanisms underlying Sertoli cell pleiotropic responses to FSH have long been investigated. But to date, only cAMP-dependent kinase… CONTINUE READING