The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma

@inproceedings{Keld2010TheEM,
  title={The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma},
  author={Richard Keld and Baoqiang Guo and Paul Downey and Christian Gulmann and Yeng S. Ang and Andrew D Sharrocks},
  booktitle={Molecular Cancer},
  year={2010}
}
Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-domain transcription factors. The PEA3 subfamily of ETS-domain transcription factors have been implicated in tumour metastasis in several different cancers. Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in oesophageal… CONTINUE READING

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