The ER glycoprotein quality control system.

@article{Dejgaard2004TheEG,
  title={The ER glycoprotein quality control system.},
  author={Selma Yilmaz Dejgaard and Johan Nicolay and Maryam Taheri and David Y. Thomas and John J. M. Bergeron},
  journal={Current issues in molecular biology},
  year={2004},
  volume={6 1},
  pages={29-42}
}
The endoplasmic reticulum (ER) is the major site for folding and sorting of newly synthesized secretory cargo proteins. One central regulator of this process is the quality control machinery, which retains and ultimately disposes of misfolded secretory proteins before they can exit the ER. The ER quality control process is highly effective and mutations in cargo molecules are linked to a variety of diseases. In mammalian cells, a large number of secretory proteins, whether membrane bound or… CONTINUE READING