The ER Repeat Protein Yt521-B Localizes to a Novel Subnuclear Compartment

  title={The ER Repeat Protein Yt521-B Localizes to a Novel Subnuclear Compartment},
  author={Oliver Nayler and Annette M Hartmann and Stefan Stamm},
  journal={The Journal of Cell Biology},
  pages={949 - 962}
The characterization of distinct subnuclear domains suggests a dynamic nuclear framework supporting gene expression and DNA replication. Here, we show that the glutamic acid/arginine-rich domain protein YT521-B localizes to a novel subnuclear structure, the YT bodies. YT bodies are dynamic compartments, which first appear at the beginning of S-phase in the cell cycle and disperse during mitosis. Furthermore, in untreated cells of the human cell line MCF7 they were undetectable and appeared only… CONTINUE READING


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