The ER/SR Ca2+ sensing protein STIM1 is essential for normal cardiomyocyte function (1150.8)

@article{Collins2014TheEC,
  title={The ER/SR Ca2+ sensing protein STIM1 is essential for normal cardiomyocyte function (1150.8)},
  author={Helen E Collins and Lan He and Betty M Pat and Luyun Zou and Jing Qu and Lufang Zhou and Silvio Litovsky and Qinglin Yang and Martin E. Young and John C. Chatham},
  journal={The FASEB Journal},
  year={2014},
  volume={28}
}
Store‐operated Ca2+ entry (SOCE) and its molecular mediator, the endoplasmic reticulum (ER) Ca2+ sensor, Stromal interaction molecule 1 (STIM1) have been implicated in hypertrophic signaling. However, since the physiological role of STIM1 in the adult heart remains unknown, we developed a cardiomyocyte‐restricted STIM1 knockout (crSTIM1‐KO) mouse. Using serial echocardiography and histological analysis, we observed a progressive decline in contractile function from 20 weeks of age, which was…