The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention

@article{Mssig2009TheEK,
  title={The ENPP1 K121Q polymorphism determines individual susceptibility to the insulin-sensitising effect of lifestyle intervention},
  author={Karsten M{\"u}ssig and Martin Heni and Claus Thamer and Konstantinos Kantartzis and Fausto Machicao and Norbert Stefan and Andreas Fritsche and H. U. H{\"a}ring and Harald Staiger},
  journal={Diabetologia},
  year={2009},
  volume={53},
  pages={504-509}
}
The K121Q (rs1044498) single nucleotide polymorphism (SNP) in the ENPP1 gene has shown association with insulin resistance and type 2 diabetes in various ethnic populations. We hypothesised that K121Q may predict the success of lifestyle intervention in terms of improvement of insulin sensitivity. We genotyped 1,563 participants with an increased risk of type 2 diabetes for K121Q and performed correlational analyses with anthropometric data and variables of insulin sensitivity. For metabolic… CONTINUE READING