The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data


The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA’s first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

DOI: 10.1007/s11682-013-9269-5

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@inproceedings{Thompson2013TheEC, title={The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data}, author={Paul M. Thompson and Jason L. Stein and Sarah E. Medland and Derrek P. Hibar and Alejandro Arias V{\'a}squez and Miguel E. Renteria and Roberto Toro and Neda Jahanshad and Gunter Schumann and Barbara Franke and Margaret J. Wright and Nicholas G. Martin and Ingrid Agartz and Martin Alda and Saud Alhusaini and Laura Almasy and Jorge R. C. Almeida and Kathryn I. Alpert and Nancy Andreasen and Ole A. Andreassen and Liana G. Apostolova and Katja Appel and Nicola J Armstrong and Benjamin S. Aribisala and Mark E. Bastin and Michael Bauer and Carrie E. Bearden and \Orjan Bergmann and Elisabeth B. Binder and John Blangero and H. Jeremy Bockholt and Erlend B\oen and Catherine Bois and Dorret I. Boomsma and Tom Booth and Ian Bowman and Janita B Bralten and Rachel M. Brouwer and Han G. Brunner and David G. Brohawn and Randy L. Buckner and Jan Buitelaar and Kazima B. Bulayeva and Juan R. Bustillo and Vince D. Calhoun and Dara M. Cannon and Rita M. Cantor and Melanie A. Carless and Xavier Caseras and Gianpiero L . Cavalleri and M. Mallar Chakravarty and Kiki D. Chang and Christopher R. K. Ching and Andrea Nikie Christoforou and Sven Cichon and Vincent P. Clark and Patricia J. Conrod and Giovanni Coppola and Benedicto Crespo-Facorro and Joanne E. Curran and Michael Czisch and Ian J. Deary and Eco J de Geus and Anouk den Braber and Giuseppe Delvecchio and Chantal Depondt and L D Dick de Haan and Greig I De zubicaray and Danai Dima and Rali Dimitrova and Srdjan Djurovic and Hongwei Dong and Gary Donohoe and Ravindranath Duggirala and Thomas D. Dyer and Stefan Ehrlich and Carl Johan Ekman and Torbj\orn Elvs{\aa}shagen and Louise Emsell and Susanne Erk and Thomas Espeseth and Jesen A. Fagerness and Scott C. Fears and Iryna O. Fedko and Guill{\'e}n Fern{\'a}ndez and Simon E. Fisher and Tatiana Foroud and Peter T. Fox and Clyde Francks and Sophia Frangou and Eva Maria Frey and Thomas Frodl and Vincent Frouin and Hugh Garavan and Sudheer Giddaluru and David C. Glahn and Beata Renata Godlewska and Rita Z. Goldstein and Randy L. Gollub and Hans J{\"{o}rgen Grabe and Oliver Grimm and Oliver Gruber and Tulio M. Guadalupe and Raquel E. Gur and Ruben C. Gur and Harald H. G{\"{o}ring and Saskia P Hagenaars and Tomas Hajek and Geoffrey B. C. Hall and Jeremy Hall and John Hardy and Catharina Annette Hartman and Johanna Hass and Sean N Hatton and Unn Kristin Haukvik and Katrin Hegenscheid and Andreas Heinz and Ian B. Hickie and Beng-Choon Ho and David Hoehn and Pieter J. Hoekstra and Marisa O. Hollinshead and Avram J. Holmes and Georg Homuth and Martine Hoogman and L. Elliot Hong and Norbert Hosten and Jouke-Jan Hottenga and Hilleke E. Hulshoff Pol and Kristy S. Hwang and Clifford R. Jack and Mark Jenkinson and Caroline E. Johnston and Erik J{\"{o}nsson and Ren{\'e} S. Kahn and Dalia Kasperavi{\vc}iūtė and Sinead Kelly and Sungeun Kim and Peter V. Kochunov and Laura Koenders and Bernd J. Kr{\"a}mer and John Kwok and Jim Lagopoulos and Gonzalo Laje and Mikael Land{\'e}n and Bennett A. Landman and John Lauriello and Stephen Lawrie and Phil H. Lee and St{\'e}phanie Le Hellard and Herv{\'e} Lema{\^i}tre and Cassandra D. Leonardo and Chiang-Shan R. Li and Benny Liberg and David C M Liewald and XinMin Liu and Lorna M. Lopez and Eva Loth and A. Lourdusamy and Michelle Luciano and Fabio Macciardi and Marise W. J. Machielsen and Glenda M. MacQueen and Ulrik F. Malt and Ren{\'e} C. W. Mandl and Dara S. Manoach and Jean-Luc Martinot and Mar Matar{\'i}n and Karen Mather and Manuel Mattheisen and Morten Mattingsdal and Andreas Meyer-Lindenberg and Colm McDonald and Andrew M. McIntosh and Francis J. McMahon and Katie L. McMahon and Eva M. Meisenzahl and Ingrid Melle and Yuri Milaneschi and Sebastian Mohnke and Grant W. Montgomery and Derek W. Morris and Eric K. Moses and Bryon A. Mueller and Susana Mu{\~n}oz Maniega and Thomas W. M{\"{u}hleisen and Bertram M{\"{u}ller-Myhsok and Benson Mwangi and Matthias Nauck and Kwangsik Nho and Thomas E. Nichols and Lars-G{\"{o}ran Nilsson and Allison C. Nugent and Lars Nyberg and Rene L. Olvera and Jaap Oosterlaan and Roel A. Ophoff and Massimo Pandolfo and Melina Papalampropoulou-Tsiridou and Martina Papmeyer and Tom{\'a}s Paus and Zdenka Pausova and Godfrey D. Pearlson and Brenda W. J. H. Penninx and Charles P. Peterson and Andrea L. Pfennig and Mary L. Phillips and G. Bruce Pike and Jean Baptiste Poline and Steven G. Potkin and Benno P{\"{u}tz and Adaikalavan Ramasamy and Jerod Rasmussen and Marcella Rietschel and Mark Rijpkema and Shannon L. Risacher and Joshua L. Roffman and Roberto Roiz-Santia{\~n}ez and Nina Romanczuk-Seiferth and Emma Jane Rose and Natalie A. Royle and Dan Rujescu and Mina Ryten and Perminder S. Sachdev and Alireza Salami and Theodore D. Satterthwaite and Jonathan Savitz and Andrew J. Saykin and Cathy Scanlon and Lianne Schmaal and Hugo G. Schnack and Andrew J. Schork and S. Charles Schulz and Remmelt R Sch{\"{u}r and Larry Seidman and Li Shen and Jody M. Shoemaker and Andrew Simmons and Sanjay Sisodiya and Colin M. Smith and Jordan W. Smoller and Jair C. Soares and Scott R. Sponheim and Emma Sprooten and John M. Starr and Vidar M. Steen and Stephen D Strakowski and Lachlan T. Strike and Jessika E. Sussmann and Philipp G. S{\"a}mann and Alexander Teumer and Arthur W. Toga and Diana Tordesillas-Gutierrez and Daniah Trabzuni and S. Trost and Jessica A. Turner and Martijn P. van den Heuvel and Nic J. A. van der Wee and Kristel R. van Eijk and Theo G M van Erp and Neeltje E. M. van Haren and Dennis van ‘t Ent and Marie-Jos{\'e} van Tol and Maria Del C Vald{\'e}s Hern{\'a}ndez and Dick J. Veltman and Amelia Versace and Henry V{\"{o}lzke and Robert L. Walker and Henrik Walter and Lei Wang and Joanna M. Wardlaw and Michael E. Weale and Michael W Weiner and Wei Wen and Lars T. Westlye and Heather C Whalley and Christopher D. Whelan and Tonya White and Anderson M. Winkler and Katharina Wittfeld and Girma Woldehawariat and Christiane Wolf and David Zilles and Marcel P. Zwiers and Anbupalam Thalamuthu and Peter R. Schofield and Nelson B. Freimer and Natalia S. Lawrence and Wayne C. Drevets}, booktitle={Brain Imaging and Behavior}, year={2013} }