The EMT regulator slug and lung carcinogenesis.

  title={The EMT regulator slug and lung carcinogenesis.},
  author={Jin-Yuan Shih and Pan-Chyr Yang},
  volume={32 9},
Lung cancer is the leading cause of cancer death worldwide. Cancer metastasis and resistance to treatment (including radiotherapy, chemotherapy and targeted therapy) are two major causes for the poor survival of lung cancer patients. Epithelial-mesenchymal transition (EMT) is involved in cancer cell invasion, resistance to apoptosis and stem cell features. The process of EMT is controlled by a group of transcriptional factors, zinc finger proteins and basic helix-loop-helix factors. Signaling… CONTINUE READING
123 Citations
59 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 123 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

Snail 2 is an essential mediator of Twist 1induced epithelial mesenchymal transition and metastasis

  • K. G. Leong
  • Cancer Res .
  • 2011

ERalpha signaling through slug regulates E - cadherin and EMT

  • Y. Wu
  • Oncogene
  • 2010

SLUG / SNAI 2 and tumor necrosis factor generate breast cells with CD 44 þ / CD 24phenotype

  • Y. W. Chu
  • BMC Cancer
  • 2010

The hypoxiacontrolled FBXL 14 ubiquitin ligase targets SNAIL 1 for proteasome degradation

  • A. Vernon
  • J . Biol . Chem .
  • 2010

Similar Papers

Loading similar papers…