The EGFR/miR-338-3p/EYA2 axis controls breast tumor growth and lung metastasis

Abstract

Dysregulation of the epidermal growth factor receptor (EGFR) promotes cancer cell growth, invasion and metastasis. However, its relevant downstream effectors are still limited. Here, we show that EGFR promotes breast tumor growth and metastasis by downregulating the tumor suppressor micoRNA-338-3p (miR-338-3p) and activating the EYA2 (EYA transcriptional… (More)
DOI: 10.1038/cddis.2017.325

Topics

  • Presentations referencing similar topics