The EBNA 1 Protein of Epstein-Barr Virus Functionally Interacts with Brd 4

@inproceedings{Lin2008TheE1,
  title={The EBNA 1 Protein of Epstein-Barr Virus Functionally Interacts with Brd 4},
  author={Ammy Lin and Shan Wang and Tin Nguyen and Kathy Shire and Lori Frappier},
  year={2008}
}
The EBNA1 protein of Epstein-Barr virus (EBV) is essential for EBV latent infection in ensuring the replication and stable segregation of the EBV genomes and in activating the transcription of other EBV latency genes. We have tested the ability of four host proteins (Brd2, Brd4, DEK, and MeCP2) implicated in the segregation of papillomavirus and Kaposi’s sarcoma-associated herpesvirus to support EBNA1-mediated segregation of EBV-based plasmids in Saccharomyces cerevisiae. We found that Brd4… CONTINUE READING
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