The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells.

@article{Bedell1987TheER,
  title={The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells.},
  author={Mary A Bedell and Kenneth H. Jones and Laimonis Laimins},
  journal={Journal of virology},
  year={1987},
  volume={61 11},
  pages={3635-40}
}
Plasmids containing the E6 and E7 open reading frames of human papillomavirus type 18 expressed from an autologous transcriptional control region were sufficient for transformation of NIH 3T3 and Rat-1 cells. Transformation by these sequences did not always involve morphological alterations even though anchorage-independent growth occurred at a high frequency. In these cells, the efficiency of transformation by the E6 and E7 construct was equivalent to or, in most cases, better than that… CONTINUE READING

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Characterization of a cell type - specific enhancer found in the human papilloma virus type 18 genome

Y.-C. Yang, H. Okayama
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