The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

@article{LeNoueNewton2011TheEU,
  title={The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.},
  author={Michele L LeNoue-Newton and Guy R. Watkins and Ping Zou and Katherine L. Germane and Lisa R McCorvey and Brian E. Wadzinski and Benjamin W. Spiller},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 20},
  pages={17665-71}
}
Protein phosphatase 2A (PP2A) is regulated through a variety of mechanisms, including post-translational modifications and association with regulatory proteins. Alpha4 is one such regulatory protein that binds the PP2A catalytic subunit (PP2Ac) and protects it from polyubiquitination and degradation. Alpha4 is a multidomain protein with a C-terminal domain that binds Mid1, a putative E3 ubiquitin ligase, and an N-terminal domain containing the PP2Ac-binding site. In this work, we present the… CONTINUE READING
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Protection of PP2Ac Requires Both Domains of Alpha4

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