The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid

@inproceedings{Zou2011TheEU,
  title={The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid},
  author={Weiguo Zou and Xi Chen and Jae Hwan Shim and Zhiwei Huang and Nicholas F. Brady and Dorothy Zhang Hu and Rebecca L Drapp and Kirsten Sigrist and L. H. Glimcher and Dallas Jones},
  booktitle={Nature Cell Biology},
  year={2011}
}
Craniofacial anomalies (CFAs) are the most frequently occurring human congenital disease, and a major cause of infant mortality and childhood morbidity. Although CFAs seems to arise from a combination of genetic factors and environmental influences, the underlying gene defects and pathophysiological mechanisms for most CFAs are currently unknown. Here we reveal a role for the E3 ubiquitin ligase Wwp2 in regulating craniofacial patterning. Mice deficient in Wwp2 develop malformations of the… CONTINUE READING

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